Dr Evangelos Giannitsis
Cardiologist, Medical Director of Chest Pain Unit, University Hospital of Heidelberg, Germany
 

Clinical Cases: Differentiating acute from chronic cardiac conditions

 
Case   64-year old man
Key signs and symptoms CTL case studies right arrow - Clinical Cases: Differentiating acute from chronic cardiac conditions Slowly increasing dyspnoea for the past 3 weeks, most recently exertional dyspnoea with minimal effort, weight gain of 3 kg in 1 week
Medical history CTL case studies right arrow - Clinical Cases: Differentiating acute from chronic cardiac conditions Dilated cardiomyopathy diagnosed 3 years ago
Clinical examination CTL case studies right arrow - Clinical Cases: Differentiating acute from chronic cardiac conditions Third heart sound, rales over both lung bases, jugular vein congested (12 cm H2O), slight ankle edema
Laboratory test
results
CTL case studies right arrow - Clinical Cases: Differentiating acute from chronic cardiac conditions
Result   Reference range
CRP 4 mg/L   <5 mg/dL
Serum creatinine 1.2 mg/dL   <9 mg/dL
GFR 90 mL/min/1.73 m2   >90 mL/min/1.73 m2
NT-proBNP 1375 ng/L   900 ng/L HF likely if 50-75 year-old (confirmation with imaging)
ECG
Atrial fibrillation, non-specific repolarisation abnormalities in leads I, II, aVL, V2 – V6.
  image
 
Troponin kinetic profile   image
 
Magnetic resonance imaging (MRI)   image
 
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Dr Giannitsis Clinical Case - 4

What is the diagnosis of this case?

 
Diagnosis
Acute decompensated heart failure with dilated cardiomyopathy
Clinically acute decompensation of chronic heart failure secondary to dilative cardio-myopathy with elevated NT-proBNP in acute heart failure. The magnetic resonance imaging (MRI) scan shows dilatation of all cardiac chambers and severely restricted systolic LV function (EF = 24 %). The cTnT-hs kinetic profile shows a non significant fluctuation of less than 50 % increase in the cTnT-hs levels. This variation is < 7 ng/L (2 hours later) and < 9.2ng/L (3 hours later) (< 20 %).

A similar profile for cTnT-hs levels could appear in case of myocarditis.
 
Conclusion
There is no rise or fall in cTnT-hs values needed for AMI diagnosis.
 

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