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53-Year old-Women
Key signs and symptoms
Acute decompensated heart failure requiring admission
for intravenous diuretic – LVEF 25%
Medical history
Diabetes mellitus for the last 3 years
Chronic heart failure for the last 2 years
Clinical examination
BP 120/80 mmHg
Heart rate 72/min
Pulmonary congestion with pedal edema
Potassium 4.2 mmol/L
Creatinine 90 Umol/L,
HbA1c 7.1%
BMI-22
Medications
Recommended Procedure
A repeat NT-proBNP result would be recommended before discharge as natriuretic peptides have prognostic value in heart failure.
For hospitalized patients, NT-proBNP should be checked at least twice at admission and before discharge.
A single value of >5000 pg/mL predicts a greater risk of mortality and poorer outcomes.
Change of NT-proBNP provides useful information for determining the optimal treatment at discharge.
Based on the admission value of >5000 pg/mL and the lack of reduction before discharge, this patient would be at high risk for mortality and heart failure rehospitalization. It impacted on the switch from enalapril to Sacubitril/Valsartan to optimize the medical therapy.
Conclusion
Patients who attained a significant reduction (>30%) in NT-proBNP between admission and discharge had a lower subsequent rate of cardiovascular death or heart failure hospitalization.
Author’s opinion:
Although the level of NT-proBNP and the change of NT-proBNP should not be used as the only criterion to determine admission and discharge of heart failure patients, NT-proBNP provides additional information to clinical evaluation in support of clinical decision on admission, triage, discharge and optimizing treatment.
References:
MR Ziles, BL Claggett, MF Prescott, et al. Prognostic Implications of Changes in N-Terminal Pro-B-type Natriuretic Peptide in Patients With Heart Failure. J Am Coll Cardiol 2016; 68: 2425-2436.
CSP Lam, YH Li, A Bayes-Genis, et al. The role of N-terminal pro-B-type natriuretic peptide in prognostic evaluation of heart failure. J Chin Med Assoc 2019; 82(6):447-451.