Dr Januzzi: BMI stratified cut-off values for NT-proBNP are, not recommended. The reason is, the age-stratified approach of 450 pg/mL, 900 pg/mL and 1800 pg/mL for people less than 50 yrs, 50 to 75 yrs, greater than 75 yrs, really addresses (to a large extent) the BMI differences. Younger patients tend to be heavier and so the cut-offs are lower for younger patients. For BNP, it is recommended to cut the cut-offs in half, so down to 50 pg/mL for patients in the obesity range.
